Curriculum Vitae Name: Sergei Alexander Grando, M.D., Ph.D., D.Sc. Title: Distinguished Professor at University of California Irvine Office: Department of Dermatology, University of California Irvine, Medical Surge II, Room 362, Irvine, CA 92697, USA. Telephone: (949) 824-2713; Fax: (949) 824-2993. Email: [email protected] Home: 15507 Orchid Avenue, Tustin, California 92782, USA. Telephone: (949) 552-4211; Fax: (949) 552-4311 I. VITAE Birth date: February 14, 1957 Birthplace: Kyiv, Ukraine Citizenship USA Professional Degrees: Institute and Location Degree Year Conferred Field of Study Medical Institute, Kyiv, Ukraine M.D. 1980 Medicine PostGraduate Institute for Physicians, Kyiv, Ukraine Ph.D. 1984 Pharmacology and Biochemistry Central Institute of Dermatology and Venereology, Moscow, Russia D.Sc. (Doctor of Science in Medicine) 1989 Immunology and Cell Biology Academic Appointments: 2007-present Professor (tenured; current Step: Above Scale), Departments of Dermatology (primary), and Biological Chemistry (secondary), University of California Irvine 1996-2007 Professor of Dermatology (tenured), Department of Dermatology, University of California Davis 1992-1996 Associate Professor of Dermatology (tenured), Department of Dermatology, University of Minnesota, 1991-1992 Visiting Professor, Department of Dermatology, University of Minnesota 1990-1991 Professor of Dermato-venereology and Immunology, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kyiv, Ukraine 1989-1990 Acting Professor, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kyiv, Ukraine 1985-1989 Assistant Professor, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kyiv, Ukraine 1984-1985 Instructor of Dermatology and Venereology, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kyiv, Ukraine Postgraduate Medical Training in Ukraine and Re-training in USA: 1996-1999 American Dermatologic Residency Experience Fulfilling the American Board of Dermatology Certification Requirements, Department of Dermatology, University of California Davis School of Medicine, Davis 1995-1996 Transitional Year Residency Program at Hennepin County Medical Center, Minneapolis, Minnesota 1980-1982 Resident in Dermatology, Department of Dermatology and Venereology, PostGraduate Institute for Physicians, Kyiv, Ukraine 1979-1980 Intern in General Medicine, Medical Institute, Kyiv, Ukraine Research Fellowships: 1984-1989 The D.Sc. (i.e., Doctor of Sciences in Medicine) Program of the Central Institute of Dermatology and Venereology (Moscow, Russia) at Kyiv State University: Departments of Biochemistry, Molecular and Cellular Biology, and Immunology 1982-1984 The Ph.D. (i.e., Candidate of Sciences in Medicine) Program at PostGraduate Institute for Physicians, Kyiv, Ukraine: Departments of Dermatology and Venereology, Pharmacological Chemistry, and Drug Development Certification/Licensure: 1999 Diplomate, American Board of Dermatology (re-certified in 2009 and 2019) 1996 Licensed, Medical Board of California 1996 Licensed, Minnesota Board of Medical Practice 1995 Certified, Educational Commission for Foreign Medical Graduates, USA 1991 Certified, Highest Qualifications in Dermatology, Venereology, and Clinical and Laboratory Immunology, the USSR Ministry of Health 1982 Certified in Dermatology and Venereology by the USSR Ministry of Health Honors: 2017 Honorary Member, the French Society of Dermatology 2017 America's Most Honored Professionals 2017 - Top 5% 2016 Best of Irvine Award 2016 Featured in Orange Coast Magazine among Top Doctors chosen by their peers 2015, 2016, 2017 Recognized among Castle Connolly Top Doctor for Irvine, CA 2013-2018 Vice Chair for Research, Department of Dermatology, UC Irvine since 2013 Included in Best Doctors in America database since 2012 HealthGrades Recognized Doctor 2010 Doctor of the Year, International Pemphigus and Pemphigoid Foundation, USA 1999-2007 Founder, International Pemphigus Research Fund (IPRF) 1996-2007 Member, Graduate Group in Immunology, University of California Davis 2000-present Former Vice Chair and current member, Medical Advisory Board of International Pemphigus and Pemphigoid Foundation 2004 Honorary Chair for California, NRCC Physicians' Advisory Board 2003 Vice Chair, Dermatology Foundation of California 2002 Honorary Member, Ukrainian Association of Dermatologists, Venereologists, Cosmetologists, Ukraine 1995 FIRST Award, NIH, NIAMS, USA 1991 Honorary Member, Belgian Royal Society of Dermatology and Venereology, Belgium 1981, 1982, 1983, 1984, 1985, 1986, 1987, 1988 Annual Award for the Best Scientific Presentation among Young Investigators, PostGraduate Institute for Physicians, Kyiv, Ukraine 1987 Award, Municipal Society for Scientists and Specialists, Kyiv, Ukraine 1988 Premium, Ukrainian Republican Society for Inventors, Kyiv, Ukraine Other Positions: 2021-present 2021-present Member, Research Award Nominations Committee, UC Irvine Director, The Immunobullous Clinic, UC Irvine Department of Dermatology 2016-2018 Representative, College of Health Sciences Academic Senate, UC Irvine 2016-present Clinical Advisor, American Academy of Dermatology, Burden of Skin Disease Work Group 2011-present Member and Ad Hoc Chair, Academic Resources Advisory Committee, UC Irvine 2009-2012 Member, Divisional Senate Assembly, UC Irvine 2009-2013 Member, Promotions & Honors Exec. Committee of the Academic Senate, UC Irvine 2007-present Faculty affiliate, UC Irvine Cancer Research Institute 2007-present Faculty member, UC Irvine Cancer Center 2007-present Faculty member, UC Irvine Institute for Immunology 2007-2015 Director, CME Program, UC Irvine Department of Dermatology 2005-2007 Faculty member, UC Davis Cancer Center 2004-2005 Member, Compensation Advisory Committee, UC Davis, School of Medicine 2001-2002 Member, Executive Committee, UC Davis Graduate Group in Immunology 2001-2007 Member, Admission Committee, UC Davis Graduate Group in Comparative Pathology 2000-2007 Faculty member, UC Davis Center of Neuroscience 2000-2001 Senior Consultant, Psoriasis Research Institute 1998-present Member (former Vice Chair), Medical Advisory Board of the International Pemphigus and Pemphigoid Foundation 1999-2007 Member, Graduate Group in Comparative Pathology, University of California Davis 1996-2007 Director, Research Laboratories, Department of Dermatology, University of California Davis 1995-1996 Director, Research Laboratories, Department of Dermatology, University of Minnesota 1994 - 1995 Member, the University of Minnesota Committee on the Use Of Human Subjects in Research, Minneapolis, Minnesota 1989 - 1991 Director, Medical and Biological Division of Scientific and Industrial Cooperative "Technobascom", Kyiv, Ukraine 1989 - 1991 Dean, Office of International Relations of PostGraduate Institute for Physicians, Kyiv, Ukraine, 1989 - 1991 Member, Scientific Council of Kyiv PostGraduate Institute for Physicians, Ukraine 1988 - 1991 Member, Scientific Council on Clinical and Experimental Immunology, the Ukr.SSR Academy of Sciences of Health, Kyiv, Ukraine, 1986 - 1991 Chief, Unit of Immunodermatology and Extracorporeal Detoxification, Central Dermato-Venereologic Hospital, Kyiv, Ukraine 1986 - 1987 Member, Advisory Committee on Liquidation of Medical and Biological Consequences of Chernobyl Disaster, the Ukr.SSR Ministry of Health, Ukraine 1978 - 1980 Chairman, the Academician Kissel Students' Scientific Society of Kyiv Medical Institute, Ukraine Meeting Organizer/Chairman 2019 Organizer, The 5th Intl. Conference on Nonneuronal Acetylcholine, Long Beach, CA 2017 Co-organizer, Scientific Meeting of International Pemphigus and Pemphigoid Foundation, Luebeck, Germany 2017 Co-organizer, Annual Meeting of International Pemphigus and Pemphigoid Foundation, Newport Beach, CA 2014 Co-organizer, The 4th Intl. Conference on Nonneuronal Acetylcholine, Giessen, Germany 2013 Member of Organizing Committee, The 2nd International Conference on Clinical & Cellular Immunology, Las Vegas, NV 2011 Co-organizer, The 3rd Intl. Conference on Nonneuronal Acetylcholine, Groningen, Holland 2011 Co-chairman, The 22nd World Congress of Dermatology, Seoul, South Korea 2010 Organizer, "Pemphigus & Pemphigoid: from the bench to the bedside," NIH, Bethesda, MD 2006 Co-chairman, Organizing Committee of the 2nd International Symposium on Nonneuronal Acetylcholine, Mainz, Germany 2005 Co-organizer, "Pemphigus 2005 - Progress and Future Directions," NIH, Bethesda, MD 2002 Chairman, Organizing Committee of the 1st International Symposium on Nonneuronal Acetylcholine, San Francisco, CA Invited Speaker/Guest Lecturer/Visiting Professor: 2022 Department of Dermatology, University of New Mexico, Albuquerque, NM 2022 California Dermatology Physician Assistant Society Symposium, Costa Mesa, CA 2022 Department of Dermatology, University of California Los Angeles, CA 2022 International Pemphigus & Pemphigoid Foundation Virtual Patient Education Conference. 2022 San Diego Dermatology Symposium, San Diego, CA 2021 International Pemphigus & Pemphigoid Foundation, Scientific Symposium, Marburg, Germany 2020 International Pemphigus & Pemphigoid Foundation Virtual Patient Education Conference. 2020 San Diego Dermatology Symposium, San Diego, CA 2020 Department of Dermatology & Cutaneous Surgery, University of Miami, Miami, FL 2019 The 8th Annual Immunoglobulin Nursing Society National Convention, Las Vegas, NV 2019 The 77th Annual Meeting of American Academy of Dermatology, Washington, DC 2019 Division of Dermatology, University of Texas Health San Antonio, TX 2019 Department of Dermatology, University of Illinois at Chicago, IL 2018 Department of Dermatology, University of Minnesota, Minneapolis, MN 2018 Department of Dermatology, Mayo Clinic, Scottsdale, AZ 2018 The 40th Annual Academician O.O. Bogomolets Seminar, National Medical University, Kyiv, Ukraine 2018 The 11th International Congress on Autoimmunity, Lisbon, Portugal 2018 Neurotransmitters: non-neuronal functions and therapeutic opportunities, Orleans, France 2018 Department of Dermatology, University of Arkansas, Little Rock, AR 2017 Annual Meeting of International Pemphigus and Pemphigoid Foundation, Newport Beach, CA 2017 Department of Dermatology, University of California San Diego, CA 2017 Department of Dermatology, The Mount Sinai Hospital, New York, NY 2017 Scientific Meeting of International Pemphigus and Pemphigoid Foundation, Luebeck, Germany 2017 The 75th Annual Meeting of American Academy of Dermatology, Orlando, FL 2016 Department of Dermatology, Wayne State University, Detroit, MI 2016 Pathogenesis of Pemphigus and Pemphigoid, Munich, Germany 2016 Annual Meeting of International Pemphigus and Pemphigoid Foundation, Austin, TX 2016 Department of Dermatology, Henry Ford Medical Center, Detroit, MI 2016 The 17th World Conference on Lung Cancer, Vienna, Austria 2016 The 10th International Congress on Autoimmunity, Leipzig, Germany 2016 The 15th International Symposium on Cholinergic Mechanisms, Marseille, France 2016 Department of Dermatology, Georgetown University, Washington, DC 2016 Department of Dermatology, University of Illinois at Chicago, IL 2016 6th Summit in Aesthetic Medicine, Newport Beach, CA 2015 Houston Dermatology Society Meeting, Houston, TX 2015 The 73rd Annual Meeting of American Academy of Dermatology, San Francisco, CA 2015 The 4th Annual Immunoglobulin Nursing Society National Convention, Washington, DC 2015 Annual Meeting of International Pemphigus and Pemphigoid Foundation, New York, NY 2015 Department of Dermatology, Stanford University, Palo Alto, CA 2015 Department of Dermatology, The Mount Sinai Hospital, New York, NY 2014 The 4th Annual Meeting of Euro-Asian Assoc. of Dermato-venereologists, Jerusalem, Israel 2014 Department of Dermatology, Rutgers New Jersey Medical School, Newark, NJ 2014 Annual Meeting of International Pemphigus and Pemphigoid Foundation, Chicago, IL 2014 Department of Dermatology, University of Minnesota, Minneapolis, MN 2014 4th Summit in Aesthetic Medicine, Dana Point, CA 2014 The 4th Intl. Conference on Nonneuronal Acetylcholine, Giessen, Germany 2014 The 9th International Congress on Autoimmunity, Nice, France 2014 Department of Dermatology, St. Louis University, St. Louis, MO 2014 The 26th Annual Meeting of Wound Healing Society, Orlando, FL 2014 The 72nd Annual Meeting of American Academy of Dermatology, Denver, CO 2014 The Florida West Coast Society of Dermatology and Department of Dermatology & Cutaneous Surgery of University of South Florida, Tampa, FL 2014 2nd International Symposium on Dermato-endocrinology, Copenhagen, Denmark 2013 Department of Dermatology, University of Arizona, Tucson, AZ 2013 The Miami Society for Dermatology and Cutaneous Surgery, Miami, FL 2013 The 2nd International Conference on Clinical & Cellular Immunology, Las Vegas, NV 2013 Investigator Sponsored Research Forum, Grifols, Raleigh, NC 2013 XI International Congress of Dermatology, New Delhi, India 2013 1st International Symposium on Dermato-endocrinology, Edinburgh, UK 2013 The Dermatology Nurse Practitioner Society of New England, Boston, MA 2013 Annual Meeting of International Pemphigus and Pemphigoid Foundation, San Francisco, CA 2013 30th Annual Conference of the Egyptian Society of Dermatology & Venerology, Cairo, Egypt 2013 International Symposium on Autoimmune Bullous Diseases, Lübeck, Germany 2013 The 71st Annual Meeting of American Academy of Dermatology, Miami, FL 2013 Department of Dermatology, Kaiser Permanente Medical Center, Los Angeles, CA 2012 The 3rd Continental Congress of Dermatology, Durban, South Africa 2012 The 13th Las Vegas Dermatology Seminar, Las Vegas, NV 2012 "Modulation of Autoimmunity" Retreat, Lübeck, Germany 2012 Summer American Academy of Dermatology Meeting, Boston, MA 2012 Annual Meeting of the European Society for Dermatological Research, Venice, Italy 2012 The 8th International Congress on Autoimmunity, Granada, Spain 2012 Annual Meeting of the International Pemphigus and Pemphigoid Foundation, Boston, MA 2012 The 70th Annual Meeting of American Academy of Dermatology, San Diego, CA 2011 Loma Linda University Medical Center, Loma Linda, CA 2011 The 20th Prof. Dr. A. Lufty Tat Symposium, Ankara, Turkey 2011 Summer American Academy of Dermatology Meeting, New York, NY 2011 Department of Dermatology, UCLA-Harbor Medical Center, Los Angeles, CA 2011 International von Behring-Röntgen Symposium “Pemphigus – from autoimmunity to disease”, Marburg, Germany 2011 The 3rd International Conference on Drug Discovery & Therapy, Dubai, U.A.E. 2011 Institute for Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany 2011 The 9th Anti-Aging Medicine World Congress & MediSpa, Monte-Carlo, Monaco 2011 Wellcome Trust Scientific Conference, Hinxton, UK 2011 The 69th Annual Meeting of American Academy of Dermatology, New Orleans, LA 2010 The 9th Ukrainian Congress of Dermatologists and Venereologists, Odessa, Ukraine 2011 The 3rd Intl. Conference on Nonneuronal Acetylcholine, Groningen, Holland 2011 The 22nd World Congress of Dermatology, Seoul, South Korea 2010 Summer American Academy of Dermatology Meeting, Chicago, IL 2010 The 13th World Congress on Cancers of the Skin, Madrid, Spain 2010 "Pemphigus & Pemphigoid: from the bench to the bedside," NIH, Bethesda, MD 2010 The 68th Annual Meeting of American Academy of Dermatology, Miami, FL 2009 Loma Linda University Medical Center, Loma Linda, CA 2009 The Scientific Conference Dedicated to the 125th Anniversary of Dept. of Dermatology of National O. O. Bohomolets Medical University, Kyiv, Ukraine 2009 International Pemphigus Meeting, Berne, Switzerland 2009 The 10th International Congress of Dermatology, Prague, Czech Republic 2009 The 67th Annual Meeting of American Academy of Dermatology, San Francisco, CA 2009 The 15th Conference of the Panamerican Society for Pigment Cell Research, Memphis, TN 2008 The 7th Annual Meeting of Flight Attendant Medical Research Institute, Boston, MA 2008 Environmental Stressors in Biology and Medicine, Siena, Italy 2008 The 66th Annual Meeting of American Academy of Dermatology, San Antonio, TX 2008 International Meeting on Autoimmune Bullous Diseases, Otsu, Japan 2008 Recent Advances in Muscarinic Receptor Pharmacology and Therapeutics, San Diego, CA 2007 The 21st World Congress of Dermatology, Buenos Aires, Argentina 2007 Frontiers of Cutaneous Biology, Greifswald, Germany 2007 The 6th Annual Meeting of Flight Attendant Medical Research Institute, Miami, FL 2007 Mini-Conference "New Horizons in Biological Roles of Acetylcholine", Tokyo, Japan 2007 The 6th Annual Meeting of Flight Attendant Medical Research Institute, Miami, FL 2007 The 80th Annual Meeting of the Japanese Pharmacological Society, Nagoya, Japan 2007 The 65th Annual Meeting of American Academy of Dermatology, Washington, D.C. 2006 Research seminar at Athenagen, Inc., Palo Alto, CA 2006 Pemphigus/Pemphigoid Satellite Symposium, Annual ESDR Meeting, Paris, France 2006 The 5th Annual Meeting of Flight Attendant Medical Research Institute, Boston, MA 2006 National Academy of Science of Ukraine, Palladin Institute of Biochemistry, Kyiv, Ukraine 2006 The Unilever Research-U.S.A., Edgewater, NJ 2006 The 5th Annual Meeting of Flight Attendant Medical Research Institute, Boston, MA 2006 Department of Dermatology, University of Southern California, Los Angeles, CA 2006 Department of Dermatology, University of Luebeck, Luebeck, Germany 2006 The 2nd International Symposium on Nonneuronal Acetylcholine, Mainz, Germany 2006 The 64rd Annual Meeting of American Academy of Dermatology, San Francisco, CA 2005 The Unilever Research-USA, Edgewater, NJ 2006 Frontiers of Cutaneous Biology, Bradford, UK 2005 Department of Dermatology, Harbor-UCLA Medical Center, Los Angeles, CA 2005 The 14th Congress of European Academy of Dermatology and Venereology, London, UK 2005 The 8th Ukrainian Congress of Dermatologists and Venereologists, Kyiv, Ukraine 2005 The 4th Annual Meeting of Flight Attendant Medical Research Institute, Miami, FL 2005 Department of Dermatology, University of California-Irvine, CA 2005 "Pemphigus 2005 - Progress and Future Directions," NIH, Bethesda, MD 2004 The 10th Anniversary Meeting of Gifu Dermatology Research Seminars, Gifu, Japan 2004 Bradford Club 2004, University of Bradford, UK 2004 Ukrainian Association of Dermatologists, Venereologists & Cosmetologists, Kyiv, Ukraine 2004 The 3rd Annual Meeting of Flight Attendant Medical Research Institute, Miami, FL 2004 Research seminar at Avon Products, Inc. Suffern, NY. 2004 First Vitiligo Researcher Conference, American Vitiligo Res. Foundation, Clearwater, FL 2004 The 25th Colombian National Dermatology Congress, Bogotá, Colombia. 2004 The International Pemphigus Foundation Meeting in Las Vegas, NV 2004 The 62nd Annual Meeting of American Academy of Dermatology, Washington, D.C. 2004 The Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL 2004 International Scientific Congress "Neurobiology of the Skin," Muenster, Germany 2004 Research conference "IVIg Treatment of Pemphigus", Bethesda, MD 2003 International Conference on Oxidative Stress in Skin Biology and Medicine, Andros, Greece 2003 The 2nd Annual Meeting of Flight Attendant Medical Research Institute, Miami, FL 2003 Symposium "Frontiers in Cutaneous Biology in 2003," Bradford, UK 2003 Department of Dermatology, USC and Westwood VA, Los Angeles, CA 2003 Department of Dermatology, Gifu University Medical School, Gifu, Japan 2003 German Armed Forces Institute of Pharmacology and Toxicology, Munich, Germany 2003 Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 2003 The 61st Annual Meeting of American Academy of Dermatology: San Francisco, CA 2003 Association for Proficiency in Skin Immunology, San Francisco, CA 2003 Skin Disease Education Foundation: Hawaii Dermatology Seminar, Maui, HI 2003 Department of Dermatology, University of California-Irvine, CA 2002 The 1st International Symposium on Nonneuronal Acetylcholine, San Francisco, CA 2002 Autoimmunity and the Skin (51st Montagna Symposium on Skin Biology), Snowmass, CO 2002 Medical Meeting of Flight Attendant Medical Research Institute, Miami, FL 2002 International Workshop on Cutaneous Neuroendocrinology, Hamburg, Germany 2002 International Meeting on Bullous Dermatoses, Groningen, The Netherlands 2002 The Unilever Research-USA, Edgewater, NJ 2002 Department of Dermatology, The Mount Sinai Hospital, New York, NY 2001 Irvin H. Blank Resident/Fellow Forum; 62nd SID Annual Meeting, Washington, D.C. 2002 Department of Dermatology, University of Miami School of Medicine, Miami, FL 2002 The 60th Annual Meeting of American Academy of Dermatology, New Orleans, LA 2002 International Pemphigus Foundation, Anaheim, CA 2001 Pemphigus as a Model of Organ-specific Autoimmune Disease, NIH, Bethesda, MD 2001 Department of Dermatology, UT Southwestern Medical Center, Dallas, TX 2000 Pemphigus'2000, Bangkok, Thailand 2000 Department of Dermatology, University of California-San Diego, CA 2000 Psoriasis Research Institute, Palo Alto, CA 2000 International Pemphigus Foundation, San Francisco, CA 1999 The Unilever Research-USA, Edgewater, NJ 1998 Symposium on Hereditary and Acquired Bullous Dermatoses, Salzburg, Austria 1998 Department of Dermatology, University of California-San Francisco, CA 1997 The 19th World Congress of Dermatology, Sydney, Australia 1996 The Cutaneous Biology Foundation, Inc, USA 1996 Department of Dermatology, Mayo Foundation and Clinics, Rochester, MN 1995 University of Texas Medical Branch, Galveston, TX 1993 Department of Pharmacology and Exp. Therapeutics, Univ. of Maryland, Baltimore, MD 1993 Department of Biochemistry, University of Minnesota, St. Paul, MN 1991 Belgian Royal Society of Dermatology and Venereology, Liege, Belgium 1991 Louis Pasteur University, Strasbourg, France 1990 Department of Dermatology at University of Southampton, UK 1990 Department of Dermatology at Royal Hallamshire Hospital, Sheffield, UK 1990 Department of Dermatology at Slade Hospital, Oxford, UK 1990 St John's Institute of Dermatology, London, UK 1990 Italian Society for Dermatology and Venereology, Venice, Italy 1989 Department of Immunology, Innsbruck University, Austria 1989 Department of Dermatology, University of Vienna, Austria Editor/Editorial Board Member 2021 - present 2020 Editorial Board: Immunologic Research Guest Editor, International Immunopharmacology 2017 – present Associate Editor of Dermatology, Frontiers in Medicine 2015 Guest Editor, International Immunopharmacology 2012 - present Editorial Board, American Journal of Clinical and Experimental Immunology 2012 Guest Editor, Life Sciences 2011 Guest Editor, Monographic issue of Autoimmunity on Immunoblistering Dermatoses 2010 - 2021 Section Editor: Autoimmunity Highlights 2010 - present Editorial Board: Experimental Dermatology 2009 - present Editorial Board, Dermatology Reports 2009 - present Editorial Board, Journal of Experimental Pharmacology 2007 Guest Editor, Life Sciences 2006 Guest Editor, Monographic issue of Autoimmunity on Pemphigus 2003 Guest Editor, Life Sciences 2003 – 2016 Editorial Consultant, Physicians' Information and Education Resource, American College of Physicians, Philadelphia, PA 2002 – present Editorial Board, Frontiers in Bioscience 2001 – present Editorial Board, Ukrainian Journal of Dermatology, Venereology, Cosmetology 1990 - 1991 Editorial Board, Problems in Dermatologic Diagnosis & Management, Newark, NJ, 1989 - 1992 Editorial Board, International Journal of Dermatology Research Grant Reviewer: 2014 – present Research Grant Reviewer, Deutschen Forschungsgemeinschaft (DFG), Germany 2010 – 2012 Research Grant Reviewer, Kentucky Lung Cancer Res. Program, Louisville, KY 2010 – present Research Grant Reviewer, The Wellcome Trust, UK 2009 – present Research Grant Reviewer, U.S. - Israel Binational Science Foundation 2009 – 2012 External Referee, British Skin Foundation, London, UK 2005 – 2010 Research Grant Reviewer, LYTMOS Group, LLC 2004 – 2006 Reviewer, Institute For Science and Health, St. Louis, MO 2004 – present Ad Hoc Reviewer or Chairperson, Center for Scientific Review, NIH, Bethesda, MD 2003 – 2006 Panel Reviewer, The Philip Morris External Research Program 2003 – 2017 Research Grant Reviewer, The American Institute of Biological Sciences 2003 – present Research Grant Reviewer, Israel Science Foundation 2001 – 2018 Expert Reviewer, National Science Foundation, Washington, D.C. Manuscript Reviewer: Since year Name of Journal 2022 2022 2022 BBA Advances International Journal of Molecular Sciences Apoptosis 2021 Frontiers in Medicine 2018 Frontiers in Immunology 2017 Scientific Reports 2016 Expert Opinion On Drug Discovery 2015 Environmental Toxicology and Pharmacology 2015 Expert Review of Clinical Pharmacology 2015 Lung 2013 Psychoneuroendocrinology 2013 JAMA Dermatology 2013 Journal of Biological Chemistry 2013 Systems Biology of Oxidative Stress 2013 Cancer Research 2013 PLoS ONE 2011 Amino Acids 2011 Dermatology Reports 2013 Acta Dermato-Venereologica 2012 Endocrine Reviews 2012 Journal of Anti-cancer Agents in Medical Chemistry 2010 Toxicology Letters 2010 Expert Review of Clinical Immunology 2010 Human Pathology 2010 Mediators of Inflammation 2010 Gerontology 2009 Current Cancer Drug Targets 2009 Lung Cancer 2009 Cellular and Molecular Life Sciences 2009 Expert Review of Dermatology 2009 Neuroscience 2009 Journal of Neuroscience Research 2008 Nature Reviews Cancer 2008 Cell Calcium 2008 Journal of Clinical Immunology 2008 International Journal of Cancer 2008 Journal of Cellular and Molecular Medicine 2008 Current Opinion in Investigational Drugs 2008 Proceedings of the National Academy of Sciences of the U.S.A. 2007 Trends in Pharmacological Sciences 2007 The International Journal of Biochemistry &Cell Biology 2007 American Journal of Clinical Dermatology 2006 New England Journal of Medicine 2006 Archives of Oral Biology 2006 Journal of Drugs in Dermatology 2006 Initial Reviewer, Abstracts for the 67th SID Meeting, Philadelphia, PA 2005 Clinical and Experimental Dermatology 2005 British Journal of Pharmacology 2005 Photochemistry and Photobiology 2005 Indian Journal of Dermatology, Venereology and Leprology 2005 Journal of Oral Pathology & Medicine 2005 Biology of the Cell 2004 International Journal of Immunopharmacology 2004 American Journal of Physiology 2004 Respiratory Research 2004 Journal of Dermatological Science 2004 European Journal of Biochemistry 2004 Archives of Dermatological Research 2004 Gene 2003 Journal of Autoimmunity 2003 Physiological Reviews 2003 Dermatology Online Journal 2003 International Immunology 2003 Laboratory Investigations 2003 Journal of Neuroimmunology 2002 Journal of Cellular Physiology 2002 Life Sciences 2002 Journal of Clinical Endocrinology & Metabolism 2002 Clinical and Experimental Immunology 2001 Clinical Immunology 2001 FASEB Journal 2001 Oncogene 2001 Journal of Neuroscience 2001 FEBS Letters 2001 Experimental Dermatology 2001 Dermatology 2001 International Journal of Dermatology 2000 Journal of Laboratory and Clinical Medicine 1999 Journal of Clinical Investigations 1999 Archives of Dermatology 1999 American Journal of Pathology 1999 IN VITRO Cellular and Developmental Biology 1997 Journal of Investigative Dermatology 1995 British Journal of Dermatology 1993 Journal of the American Academy of Dermatology 1992 Autoimmunity 1992 Journal of the European Acad of Dermatology and Venereology Professional Societies: 2020-present American Medical Association 2011-present American Association for Cancer Research 2008-present Panamerican Society for Pigment Cell Research 2004-present International Society of Dermatology 2004-present American College of Physicians 2003-2007 American Society for Biochemistry and Molecular Biology 2001-2015 Medical Dermatology Society 1998-present Fellow of the American Academy of Dermatology 1996-2007 Sacramento Valley Dermatological Society 1995-present Ukrainian Medical Association of North America 1993-2018 Dermatology Foundation (Leaders Society) 1993-present The Society for Investigative Dermatology 1980-present Ukrainian Association of Dermatologists, Venereologists, Cosmetologists Research Funding: As a Principal Investigator (PI): Project duration Granting agency/Type of Award Project Title Amount of the Award 2023 Dysimmune Diseases Foundation Characterization of the cellular and molecular mechanisms whereby m3 muscarinic acetylcholine receptor controls epidermal structure and function. $100,000 2022 Dysimmune Diseases Foundation Elucidation of mechanism of action of autoantibody to m3 muscarinic acetylcholine receptor that predicts disease relapse in pemphigus vulgaris patients treated with the IVIg-containing multidrug protocol $75,000 2021 Dysimmune Diseases Foundation Development of a bioassay predicting disease relapse in pemphigus vulgaris patients treated with the IVIg-containing multidrug protocol – The second year extension. $75,000 2021 Allergan Evaluation of Allergan compounds in an in vitro model for sebum production with human sebocyte cells (SEB-1). $124,342 2020 Dysimmune Diseases Foundation Development of a bioassay predicting disease relapse in pemphigus vulgaris patients treated with the IVIg-containing multidrug protocol $75,000 2020 Allergan Evaluation of Allergan compounds in an in vitro model for sebum production with human sebocyte cells (SEB-1). $113,686 2019 Dysimmune Diseases Foundation Identification of laboratory parameters predicting the therapeutic response of pemphigus patients to IVIg therapy. $75,000 2019 Allergan Fifth extension of proof-of-concept study of inhibition of sebocyte proliferation and lipid synthesis by AGN compounds' $113,686 2018-2019 Allergan Fourth extension of proof-of-concept study of inhibition of sebocyte proliferation and lipid synthesis by AGN compounds' $55,830 2017-2018 Allergan Third extension of proof-of-concept study of inhibition of sebocyte proliferation and lipid synthesis by anti-cholinergic drugs $85,000 2017-2019 NIH, NCATS/R13 5th International Symposium on Non-neuronal Acetylcholine: From Bench to Bedside $20,000 2017-2018 Grifols Therapeutics Inc Retrospective analysis of clinical outcome in patients with pemphigus treated with high-dose IVIg adjuvant therapy $75,000 2016-2017 Allergan Characterization of recombinant SLURP-1 and SLURP-2 proteins in corneal epithelial cell culture $54,075 2016-2017 Allergan Extension of proof-of-concept study of inhibition of sebocyte proliferation and lipid synthesis by anti-cholinergic drugs $82,843 2016-2017 UC Irvine Elucidating the role of eosinophil degranulation proteins on the basement membrane: Identifying a direct pathogenic mechanism of eosinophils in bullous pemphigoid $47,000 2015-2016 Allergan Proof-of-concept study of inhibition of sebocyte proliferation and lipid synthesis by anti-cholinergic drugs $50,000 2013-2014 Grifols Therapeutics Inc Proof-Of-Concept Study Of IVIg Efficacy in Patients with Cutaneous Lupus Erythematosus $219,343 2012-2014 Pfizer Sirolimus For the Treatment of Pemphigus Vulgaris Free drug supply 2012-2014 American Lung Association Nicotinergic Control of Lung Cancer $200,000 2012-2013 Department of Defense Nicotinic Receptor Polymorphism in Lung Cancer $115,000 2011-2012 Lung Cancer Research Foundation Potential of Nicotinic Antagonists for Pharmacologic Control of Lung Cancer $50,000 2010-2015 NIH, NIEHS/R01 Nicotinic Receptor Ligands and Tobacco-Induced Lung Cancer $1,720,216 2010-2011 NIH, NIAMS/R13 Pemphigus & Pemphigoid: from the bench to the bedside $20,000 2008-2013 NIH, NIDCR/R01 Epithelial Acetylcholine in Oral Biology and Pathology $1,854,317 2007-2010 Institute For Science and Health/Research Grant Receptor-mediated Mechanisms of Tobacco-Induced Lung Oncogenesis $500,000 2006-2009 NIH, NIEHS/R21 Nicotinic receptor-mediated Action of Tobacco Nitrosamines On Bronchial Cells $416,875 2005-2011 NIH, NIGMS/R01 Regulation of Keratinocyte Migration by Acetylcholine $1,687,500 2005-2008 NIH, NCI/R03 Can Nicotinic Antagonists Prevent Tobacco Smoke-induced Lung Tumors in A/J Mice? $151,500 2002-2007 NIH, NIDCR/R01 Epithelial Acetylcholine in Oral Biology and Pathology $1,299,156 2005-2008 Flight Attendant Medical Research Institute/Research Award Nicotinic Receptors Alter Gene Expression in Keratinocytes $324,000 2002-2005 NIH, NIGMS/R01 Regulation of Keratinocyte Migration by Acetylcholine $779,625 2002-2005 Flight Attendant Medical Research Institute/Research Award Precocious Skin Aging Due to Second Hand Smoke $325,500 2002-2005 The Robert Leet & Clara Guthrie Patterson Trust Development of Non-steroidal Treatment of Pemphigus $36,000 1999-2003 Unilever Research/Private Contract Cholinergic Control of Skin Aging $497,369 1998-2001 The Smokeless Tobacco Research Council-USA/Research Grant The Cholinergic System of Oral Epithelium: Structure and Biomedical Significance $278,340 1995-2002 NIH, NIAMS/R29 Cholinergic Control of Keratinocyte Migration $499,528 1996-1999 Unilever Research/Private Contract Cholinergic Networks of Young vs. Aged and Photodamaged vs. Non-photodamaged Skin $465,450 1995-1998 The Council for Tobacco Research - U.S.A., Inc/Research Grant Keratinocyte Cholinergic Receptors in Pemphigus Autoimmunity $244,500 1994-1995 Minnesota Medical Foundation/Research Grant Physiological and Pathological Significance of Keratinocyte Cholinergic Receptors $17,500 1992-1993 Dermatology Foundation/Research Grant Subtypes of Cutaneous Muscarinic Receptors $10,000 1992-1993 University of Minnesota Graduate School/Research Grant Biological Functions of Keratinocyte Cholinergic System $8,500 1991-1992 Minnesota Medical Foundation/Research Grant Keratinocyte Cholinergic System $7,500 As a Co-investigator: 2010 University of California, Cancer Research Coordinating Committee: "Genetic polymorphisms of nicotinic acetylcholine receptors that increase the risk for cancer of the cervix and other smoking related carcinomas" (PI: Hans-Ulrich Bernard, PhD) 2005 NIH, NIAMS/R13 " Pemphigus 2005 - Progress and Future Directions (PI: Jean-Claude Bystryn, MD 1994 NIH, NIDA/P01: "Nicotinic receptors in non-neuronal cells as targets for nicotine toxicity" (PI: Bianca M. Conti-Fine, MD) 1993 Dermatology Foundation: "Novel techniques for culturing basal cell carcinoma" (PI: Christopher B. Zachary, MBBS, FRCP) 1993 Minnesota Medical Foundation: "Reproduction of basal cell carcinoma in nude mice" (PI: Christopher B. Zachary, MBBS, FRCP) 1991 Minnesota Medical Foundation: "Effects of mannan on keratinocyte morphology" (PI: Mark V. Dahl, MD) Advisees (junior faculty/fellows/graduate and postgraduate students) in USA: Sébastien de Feraudy, M.D., PhD., Associate Professor of Dermatology Kyle Amber, MD, dermatology resident Anand K. Ganesan, MD, PhD, Assistant Professor of Dermatology Intratumoral heterogeneity during melanoma progression." University of California-Irvine (2015-2018) "Role of MBP in subepidermal detachment of keratinocytes in bullous pemphigoid" University of California-Irvine (2015-2018) NIH, NIAMS, 1K08ARO56001-01A1 “Aldehyde Dehydrogenase: A Novel Regulator of Melanin Biogenesis.” University of California-Irvine (2008-2013) Annette Czernik, MD, immunodermatology fellow "Immunoblistering dermatoses". University of California-Irvine (2009-2012) Arisa Ortiz, MD, dermatology resident "Smoking in dermatology". University of California-Irvine (2000-2012) Jing Qian, PhD, postdoctoral fellow "Cholinergic system of murine T lymphocytes.” University of California-Irvine (2008-2011) Courtney Philips, medical student "Biologic effects of sera from patients with Grover's disease" University of California-Irvine (2009-2011) Vivian Gindi, MD, postdoctoral fellow "The immunopathology of Grover's disease". University of California-Irvine (2009-2010) Steve Marchenko, medical student "Autoimmunity to new keratinocyte antigens in pemphigus". University of California-Irvine (2008-2011) Vu T. Nguyen, PhD student, postdoctoral fellow “Non-desmoglein targets of pemphigus autoimmunity” University of California-Davis (1996-2001) Juan Arredondo, PhD, postdoctoral fellow The role for cholinergic system of oral epithelium in mediating nicotine effects in the upper digestive tract University of California-Davis (2000-2002) Leon Hall, PhD, postdoctoral fellow “The cholinergic system of oral epithelium.” University of California-Davis (1998-2000) A. S. Sodhi, MD/PhD student "Regulation of angiogenesis and tumorigenesis by Kaposi's sarcoma associated herpesvirus genes." HHMI-NIH (1997-2000) Rico. Buchli, PhD, postdoctoral fellow “Cholinergic enzymes and receptors of skin melanocytes and fibroblasts.” University of California-Davis (1997-1999) O. M. Memar, MD/PhD student "The characterization of pemphigus vulgaris antigen expressed in insect cells: induction of blister-causing antibodies." The University of Texas Medical Branch at Galveston (1990-1995) Advisees (graduate and postgraduate students/fellows) in Ukraine: A.I. Chernyavsky, Ph.D., biochemistry/immunology fellow "The role of serine proteases in mediating cellular cytotoxic reactions." College of Biological Sciences at Kyiv State University, Ukraine (1990-1995) A.I. Kurchenko, M.D., pharmacology/immunology fellow "The immunocorrection with thymic hormone preparations in treatment of patients with eczema." PostGraduate Institute for Physicians, Kyiv, Ukraine (1988-1992) T.A. Korostash, Ph.D., pharmacology/cell biology fellow "The mechanisms of action of the immunosuppressors prednisolone and doxycycline on lymphocyte subpopulations." College of Biological Sciences at Kyiv State University, Ukraine (1986-1991) External Examiner: 2009 - M.F. Vladimirsky Regional R&D Clinical Institute, Moscow, Russia; Candidate: N.V. Makhneva - Doctor of Medical Science. 2007 - University of Sheffield, Sheffield, UK; Candidate: D.J. Gawkrodger - Doctor of Science. 2006 - Palladin Institute of Biochemistry, Kyiv, Ukraine; M. Skok - Doctor of Biological Science. 2004 - University of Bradford, Bradford, UK; Candidate: S.M.A.O. Elwary - PhD.II. Bibliography Total, excluding abstracts and audio-visuals, 285 (211 in English and 74 in Russian or Ukrainian). Abstracts - 171, Audio-visuals - 5. As of 4/9/21: H-index 70; citations 13,078. Books, Book Chapters, and Other Monographs
Original Reports
Abstracts (##1-16 are in Russian and the rest are in English)
Audio-visual 1. Grando SA: Paraneoplastic autoimmune multiorgan syndrome (PAMS). Dialogues in Dermatology, American Academy of Dermatology, 2004; vol 54, No.1 2. Grando SA: Smoking and the skin. Dialogues in Dermatology, American Academy of Dermatology, 2011; vol. 67, No.12. 3. Grando SA: The epidermis and blistering disorders: pemphigus, in Tobin, D.J. (ed.), Skin Biology, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London, 2014, (online at http://hstalks.com/?t=BL1813597-Grando). 4. Grando SA: The popularity of e-cigarettes and issues with nicotine. The Video Journal of Oncology, 2016 (http://www.vjoncology.com/video/9nj8llapkyq-the-popularity-of-e-cigarettes-and-issues-with-nicotine). 5. Grando SA: The role of nicotine in cancer and its impact on therapy, The Video Journal of Oncology, 2016 (http://www.vjoncology.com/video/s2ry8fviaaa-the-role-of-nicotine-in-cancer-and-its-impact-on-therapy). 6. Korman NJ, Werth V, Grando S, Sinha A: Closer Look at Pemphigus Vulgaris: Clinical Challenges and Emerging Treatments, MedScape, 12/7/2017) (https://www.medscape.org/viewarticle/883002 |